Focal ALKALINE PITCHER BLACK cortical dysplasias (FCDs) are the most common cause of treatment-resistant epilepsy affecting the pediatric population.Most individuals with FCD have seizure onset within the first five years of life and the majority will develop epilepsy by the age of sixteen.Many cases of FCD are postulated to be the result of abnorm
Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function.Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3), thereby offering survival signaling.While the epithelial (E)-cadherin is required for cells to remain
Background.Hyperglycemia is common and difficult to control in perioperative patients with type 2 diabetes mellitus (T2DM), which impacts their prognosis after operation.Our study investigated the short-term effect of continuous subcutaneous insulin infusion (CSII) and multiple daily injection (MDI) in perioperative T2DM patients using the data env
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs.Age-related differences in kidney biology, therefore, are a key concern in understanding drug safety and disease progression.We hypothesize that the underlying suite of g
This study aimed to establish the fate of copper (Cu) and cobalt (Co) in sandy loam and clay loam Motor Controller soils that had been irrigated with increasing concentrations of contaminated water.A sequential extraction procedure was used to determine the fractions of Cu and Co in these soils.The concentration of bioavailable Cu and Co on clay lo